Fabrication of conical microneedles array using photolithography

Polymeric Microneedle Array Fabrication by Photolithography.

This manuscript describes the fabrication of polymeric microneedle (MN) arrays by photolithography. It involves a simple mold-free process by using a photomask consisting of embedded micro-lenses. Embedded micro-lenses were found to influence MN geometry (sharpness). Robust MN arrays with tip diameters ranging between 41.5 µm ± 8.4 µm and 71.6 µm ± 13.7 µm, with two different lengths (1,336 µm ...

A Photolithographic Approach to Polymeric Microneedles Array Fabrication

In this work, two procedures for fabrication of polymeric microneedles based on direct photolithography, without any etching or molding process, are reported. Polyethylene glycol (average molecular weight 250 Da), casted into a silicone vessel and exposed to ultraviolet light (365 nm) through a mask, cross-links when added by a commercial photocatalyzer. By changing the position of the micronee...

Protein encapsulation in polymeric microneedles by photolithography

BACKGROUND Recent interest in biocompatible polymeric microneedles for the delivery of biomolecules has propelled considerable interest in fabrication of microneedles. It is important that the fabrication process is feasible for drug encapsulation and compatible with the stability of the drug in question. Moreover, drug encapsulation may offer the advantage of higher drug loading compared with ...

A scalable fabrication process of polymer microneedles

While polymer microneedles may easily be fabricated by casting a solution in a mold, either centrifugation or vacuumizing is needed to pull the viscous polymer solution into the microholes of the mold. We report a novel process to fabricate polymer microneedles with a one-sided vacuum using a ceramic mold that is breathable but water impermeable. A polymer solution containing polyvinyl alcohol ...

DIY fabrication of microstructures by projection photolithography

Previous hobbyists have demonstrated fabrication of single macroscale transistors and simple gates in silicon. These experiments, however, have been hampered by the inability to create features much below 1mm in size. This paper presents a simple and affordable projection photolithography technique which can be used to create microstructures using easily obtainable materials. Methods of alignme...

Photolithography in Fabrication of Thin-film Solar Cells